Renal Tubular Acidosis

It is a medical condition that involves an accumulation of acid in the body due to a failure of the kidneys to appropriately acidify the urine. In renal physiology, when blood is filtered by the kidney, the filtrate passes through the tubules of the nephron, allowing for exchange of salts, acid equivalents, and other solutes before it drains in to the bladder as urine. The metabolic acidosis that results from RTA may be caused either by failure to reabsorb sufficient bicarbonate ions from the filtrate in the early portion of the nephron or by insufficient secretion of hydrogen ions in to the latter portion of the nephron. Although a metabolic acidosis is also occurs in those with chronic kidney disease.